Piceatannol Lowers the Blood Glucose Level in Diabetic Mice
نویسندگان
چکیده
منابع مشابه
Piceatannol lowers the blood glucose level in diabetic mice.
We previously found that passion fruit (Passiflora edulis) seeds contained a high amount of piceatannol (3,5,3',4'-trans-tetrahydroxystilbene), a natural analog of resveratrol (3,5,4'-trans-trihydroxystilbene). Resveratrol has been proposed as a potential anti-metabolic disorder compound, by its activation of sirtuin and AMP-activated protein kinase. Many reports show that resveratrol ameliorat...
متن کاملEpidermal growth factor increases insulin secretion and lowers blood glucose in diabetic mice
Epidermal growth factor (EGF) is synthesized in the pancreas and diabetic animals have low levels of EGF. However, the role of EGF in regulating the major function of the pancreas, insulin secretion, has not been studied. Here, we show that EGF rapidly increased insulin secretion in mouse pancreatic islets, as well as in a pancreatic beta-cell line. These events were dependent on a Ca(2+) influ...
متن کاملPTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.
The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was investigated using an antisense oligonucleotide in ob/ob and db/db mice. PTP1B antisense oligonucleotide treatment normalized plasma glucose levels, postprandial glucose excursion, and HbA(1C). Hyperinsulinemia was also reduced with improved insulin sensitivity. PTP1B protein and mRNA were reduced in liver and fat with no effec...
متن کاملVariations of blood glucose level in non-diabetic patients before and after Electroconvulsive Therapy
Introduction: Application of electroconvulsive therapy (ECT) for the induction of generalized seizure was first introduced in 1938. It is applied for disorders as severe depression particularly for cases which do not respond to drug therapy, or during pregnancy when medication is detrimental to the fetus. The debate on the effect of ECT on blood glucose level is still contradictory. However, st...
متن کاملEffect of Securigera securidaca Seeds on Blood Glucose Level of Normal and Diabetic Rats
The search for indigenous natural antidiabetic agents is still ongoing. Securigera securidaca seeds are reputed in folk medicine for their value as an antidiabetic remedy, so the present study was carried out to investigate the hypoglycemic efficacy in both normal and streptozotocine (STZ)-induced diabetic rats. Hydroalcoholic extract of the seeds were administe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2015
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b15-00009